尼日利亚人群中的α1-抗胰蛋白酶表型
Alpha 1-antitrypsin phenotypes in a Nigerian population.
作者信息
Olusi S O, Ladipo G O, Ojutiku O O
出版信息
Afr J Med Med Sci. 1982 Sep-Dec;10(3-4):113-7.
Alpha 1-antitrypsin phenotypes of 350 normal Nigerian blood donors were determined by isoelectric focusing in polyacrylamide gel. The distributions obtained (MM, 66.86%; MS, 16.29%; MZ, 0.57%; SS, 2.0%; SZ, 0.28%) were different from those reported for caucasian populations. Forty-nine of these donors could not be classified into any of the above common phenotypes suggesting that some rare alleles occur in Nigeria. The probable cause and implications of the high frequency of the S gene in the Nigerian population are discussed.
通过聚丙烯酰胺凝胶等电聚焦法测定了350名尼日利亚正常献血者的α1-抗胰蛋白酶表型。所获得的分布情况（MM型，66.86%；MS型，16.29%；MZ型，0.57%；SS型，2.0%；SZ型，0.28%）与报道的高加索人群的分布情况不同。其中49名献血者无法归类为上述任何一种常见表型，这表明尼日利亚存在一些罕见等位基因。文中讨论了尼日利亚人群中S基因高频率出现的可能原因及影响。
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