志贺氏菌对美西林、萘啶酸、甲氧苄啶及其他五种抗菌剂的敏感性。
Susceptibility of shigellae to mecillinam, nalidixic acid, trimethoprim, and five other antimicrobial agents.
作者信息
Hansson H B, Walder M, Juhlin I
出版信息
Antimicrob Agents Chemother. 1981 Feb;19(2):271-3. doi: 10.1128/AAC.19.2.271.
A total of 199 strains of shigella (1 Shigella dysenteriae, 15 S. boydii, 47 S. flexneri, and 136 S. sonnei) isolated in Malmö, Sweden, within a 3-year period (1977 through January 1980) were tested with the agar plate dilution method for susceptibility to commonly used and newer antimicrobial agents. Mecillinam, nalidixic acid, and trimethoprim had the best in vitro activity. S. flexneri dominated among strains resistant to three or more antimicrobial agents and were less susceptible to ampicillin, chloramphenicol, and doxycycline than other types studied. Sixty-four percent of the strains were resistant to sulfamethoxazole. In vitro, a synergistic effect with trimethoprim was shown only in strains susceptible to sulfamethoxazole. The amidinopenicillin mecillinam was highly active against shigellae. When resistance occurred, it was linked to ampicillin in 17 of 18 strains. The quinolines, here represented by nalidixic acid, might be the drugs of choice.
在瑞典马尔默3年期间（1977年至1980年1月）分离出的总共199株志贺氏菌（1株痢疾志贺氏菌、15株鲍氏志贺氏菌、47株福氏志贺氏菌和136株宋内氏志贺氏菌），采用琼脂平板稀释法检测了对常用和新型抗菌药物的敏感性。美西林、萘啶酸和甲氧苄啶具有最佳的体外活性。在对三种或更多抗菌药物耐药的菌株中，福氏志贺氏菌占主导地位，并且比其他研究类型的菌株对氨苄西林、氯霉素和强力霉素更不敏感。64%的菌株对磺胺甲恶唑耐药。在体外，仅在对磺胺甲恶唑敏感的菌株中显示出与甲氧苄啶的协同作用。脒基青霉素美西林对志贺氏菌具有高度活性。当出现耐药性时，18株菌株中有17株与氨苄西林有关。以萘啶酸为代表的喹啉类药物可能是首选药物。
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