1,25-二羟胆钙化醇在人甲状腺髓样癌中的特异性结合
Specific binding of 1,25-dihydroxycholecalciferol in human medullary thyroid carcinoma.
作者信息
Freake H C, MacIntyre I
出版信息
Biochem J. 1982 Jul 15;206(1):181-4. doi: 10.1042/bj2060181.
Abstract
A specific 1,25-dihydroxycholecalciferol-binding protein has been detected in high-salt cytosols prepared from human medullary thyroid carcinomas. The binding protein had the same equilibrium dissociation constant (Kd = 0.17 +/- 0.05 nM; n = 4) and sedimentation coefficient on sucrose gradients (3.7S) as than seen in established vitamin D target tissues. This protein was not detected in normal thyroid cytosols, which may reflect the low proportion of C-cells within the gland.
摘要
在从人甲状腺髓样癌制备的高盐细胞溶质中检测到一种特异性的1,25 - 二羟胆钙化醇结合蛋白。该结合蛋白具有与已确定的维生素D靶组织中所见相同的平衡解离常数（Kd = 0.17±0.05 nM；n = 4）和在蔗糖梯度上的沉降系数（3.7S）。在正常甲状腺细胞溶质中未检测到这种蛋白，这可能反映了腺体中C细胞的比例较低。
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