Stevenson J C, Myers C H, Ajdukiewicz A B
Calcif Tissue Int. 1984 Dec;36(6):725-8. doi: 10.1007/BF02405396.
Profound racial differences exist in the incidence of osteoporosis, particularly in women. To investigate possible underlying reasons for this, we have measured the circulating levels of calcitonin (iCT), a bone-protecting hormone, and its flanking peptide, katacalcin (iKC), in black Gambian and white British populations. Whilst sex differences in both peptides were observed, with males having higher levels than females, the most striking finding was that white women have the lowest iCT levels. This important observation may explain, at least in part, why osteoporosis is particularly a disease of white, postmenopausal women.
骨质疏松症的发病率存在显著的种族差异，尤其是在女性中。为了探究其潜在原因，我们测量了冈比亚黑人及英国白人人群中骨保护激素降钙素（iCT）及其旁侧肽katacalcin（iKC）的循环水平。虽然在这两种肽中均观察到了性别差异，男性水平高于女性，但最显著的发现是白人女性的iCT水平最低。这一重要观察结果至少可以部分解释为何骨质疏松症尤其在绝经后白人女性中高发。
