Carr K D, Bonnet K A, Simon E J
Brain Res. 1982 Aug 12;245(2):389-93. doi: 10.1016/0006-8993(82)90824-1.
Rats were trained to press a lever to escape electrical stimulation of the nucleus reticularis gigantocellularis and to obtain stimulation of the lateral hypothalamus. Morphine sulfate and ethylketocyclazocine (EKC) both elevated the intensity of stimulation required to sustain escape at doses which did not affect self-stimulation. Parallel dose-response lines were obtained for the two opioid agonists but the effect of EKC was more resistant to naloxone antagonism. These results suggest that both mu-and chi-sub-types of opiate receptor mediate the inhibition of supraspinally-elicited aversion.
训练大鼠按压杠杆以逃避巨细胞网状核的电刺激，并获得下丘脑外侧的刺激。硫酸吗啡和乙基酮环唑辛（EKC）在不影响自我刺激的剂量下，均提高了维持逃避所需的刺激强度。两种阿片类激动剂得到了平行的剂量反应曲线，但EKC的作用对纳洛酮拮抗更具抗性。这些结果表明，阿片受体的μ和χ亚型均介导对脊髓上诱发厌恶的抑制。
