Saavedra J M, Chevillard C
Brain Res. 1982 Aug 19;246(1):157-60. doi: 10.1016/0006-8993(82)90156-1.
The activity of the angiotensin-converting enzyme (ACE) (kininase II, EC 3.4.15.1) was examined in 5 discrete hypothalamic nuclei of rats lacking vasopressin (homozygous Brattleboro rats, DI, di/di) and their corresponding controls (heterozygous Brattleboro rats, HZ, di/+, and Long Evans, LE, +/+ rats), with and without hormonal replacement with arginine-vasopressin (AVP). DI rats showed a vasopressin-reversible increased ACE activity when compared with LE controls, HZ rats showing intermediate activity. These changes occurred only in the supraoptic and periventricular hypothalamic nuclei, and were absent in other hypothalamic areas studied, including the paraventricular nucleus. These results provide biochemical evidence in support of previous anatomical and physiological data, for an interaction between the brain vasopressin and angiotensin systems in discrete hypothalamic nuclei, and suggest that vasopressin could regulate the formation of brain angiotensin II by modulating the activity of the converting enzyme.
在缺乏血管加压素的大鼠（纯合布拉特洛伯大鼠，DI，di/di）及其相应对照（杂合布拉特洛伯大鼠，HZ，di/+，和朗·埃文斯大鼠，LE，+/+大鼠）的5个离散下丘脑核中，检测了血管紧张素转换酶（ACE）（激肽酶II，EC 3.4.15.1）的活性，检测时有无用精氨酸血管加压素（AVP）进行激素替代。与LE对照相比，DI大鼠表现出血管加压素可逆性的ACE活性增加，HZ大鼠表现出中等活性。这些变化仅发生在视上核和室旁下丘脑核，在所研究的其他下丘脑区域包括室旁核中未出现。这些结果为先前的解剖学和生理学数据提供了生化证据，支持脑内血管加压素和血管紧张素系统在离散下丘脑核中的相互作用，并表明血管加压素可通过调节转换酶的活性来调节脑内血管紧张素II的形成。
