Arvidson G, Josefsson J O
Eur J Cell Biol. 1982 Aug;28(1):34-8.
Lysolecithin was found to modify cation-induced pinocytosis in Amoeba proteus. It is shown here that lysolecithin (LPC) in the concentration range of 10(-15) to 10(-10) g/ml has the same effect on Na+ -induced pinocytosis as cAMP and a pinocytosis regulating factor (PRF) which is secreted by the amoeba. Thus, LPC activated Na+-induced pinocytosis in starved amoebae and decreased the sensitivity to the inducer in normal cells. Pinocytosis depressed by treatment with EGTA or dibucaine became normal upon addition of LPC to the inducer. These effects were also obtained with lysolecithin isolated from the amoeba. It is suggested that PRF and amoeba LPC may be closely related and that phospholipase activity of the amoeba may regulate its capacity for pinocytosis.
发现溶血卵磷脂可改变变形虫中阳离子诱导的胞饮作用。本文表明，浓度范围为10（-15）至10（-10）g/ml的溶血卵磷脂（LPC）对Na +诱导的胞饮作用具有与cAMP以及变形虫分泌的胞饮作用调节因子（PRF）相同的作用。因此，LPC激活了饥饿变形虫中Na +诱导的胞饮作用，并降低了正常细胞对诱导剂的敏感性。用EGTA或地布卡因处理后受到抑制的胞饮作用，在向诱导剂中添加LPC后恢复正常。从变形虫中分离出的溶血卵磷脂也获得了这些效果。有人提出，PRF和变形虫LPC可能密切相关，并且变形虫的磷脂酶活性可能调节其胞饮能力。
