Provodnikova A S, Bogdanov N G, Sharaev P N
Vopr Pitan. 1978 Jan-Feb(1):40-3.
The influence of ascorbic acid on the content and intracellular distribution of ubiquinone in the tissues of K-avitaminotic rats was investigated. Following introduction of pelentan (30--40 mg/kg), a vitamin K antagonist, a rise in the level of ubiquinone in all of the study organs, occurring both at the expense of the post-mitochondrial fraction of the liver, heart, spleen and also at that of the cardiac and splenic mitochondria, could be registered. The ubiquinone concentration in hepatic mitochondria was going down. In K-avitaminotic rats, which received ascorbic acid, the co-enzyme content in the tissues approached control values. Vitamin C exerted a positive action on the ubiquinone level in the mitochondria of the liver, heart and spleen. The cited data suggest that vitamin C abolishes manifestations of the K-vitamin deficiency affecting the ubiquinone pool and secures its optimal content in the mitochondria. Considering the significance of vitamins K, C and ubiquinone in the tissular redox processes an interaction of the said vitamins at the level of the tissue respiration chain is presumed.
研究了抗坏血酸对K-维生素缺乏大鼠组织中泛醌含量及细胞内分布的影响。在引入维生素K拮抗剂培他宁（30 - 40毫克/千克）后，可记录到所有研究器官中泛醌水平的升高，这既源于肝脏、心脏、脾脏线粒体外部分，也源于心脏和脾脏线粒体。肝脏线粒体中泛醌浓度下降。在接受抗坏血酸的K-维生素缺乏大鼠中，组织中的辅酶含量接近对照值。维生素C对肝脏、心脏和脾脏线粒体中的泛醌水平产生了积极作用。上述数据表明，维生素C消除了影响泛醌池的K-维生素缺乏表现，并确保其在线粒体中的最佳含量。考虑到维生素K、C和泛醌在组织氧化还原过程中的重要性，推测上述维生素在组织呼吸链水平上存在相互作用。
