Pushina N G
Vopr Pitan. 1982 May-Jun(3):36-42.
Experiments on rats were made to study the content of ascorbic (AA), Dehydroascorbic (DAA) and diketogulonic (DKGA) acids in the blood serum, daily urine, liver, adrenal, kidney, spleen and lung tissues under varying body supply with vitamin K. The rats with vitamin K deficiency manifested the decreased content of AA, DAA and the elevated content of DKGA in the blood serum, daily urine and test tissues. The percentage of AA absorption by blood proteins was found to be increased upon vitamin K deficiency in the body. The changes in AA metabolism correlated with the reduced capillary resistance. Administration of AA to rats with vitamin K deficiency led to an increase in the content of AA, DAA and to a lowering of DKGA in the blood serum and tissues promoting the normalization of capillary resistance. The data obtained attest to the dependence of AA metabolism on the body supply with vitamin K, pointing to the necessity of exercising the control over AA metabolism in different forms of vitamin K deficiency.
通过对大鼠进行实验，研究在不同维生素K机体供应情况下，血清、每日尿液、肝脏、肾上腺、肾脏、脾脏和肺组织中抗坏血酸（AA）、脱氢抗坏血酸（DAA）和二酮古洛糖酸（DKGA）的含量。维生素K缺乏的大鼠在血清、每日尿液和受试组织中表现出AA、DAA含量降低以及DKGA含量升高。发现机体维生素K缺乏时，血液蛋白质对AA的吸收百分比增加。AA代谢的变化与毛细血管阻力降低相关。给维生素K缺乏的大鼠施用AA导致血清和组织中AA、DAA含量增加以及DKGA含量降低，促进毛细血管阻力正常化。所获得的数据证明AA代谢依赖于机体对维生素K的供应，表明在不同形式的维生素K缺乏情况下控制AA代谢的必要性。
