Taugner R, Ganten D
Histochemistry. 1982;75(2):191-201. doi: 10.1007/BF00496010.
An antibody against pure rabbit lung converting enzyme (CE) showing cross-reaction with CE from other species was used for immunocytochemical studies in the kidney of rats. Using the indirect labelling PAP-technique, specific immunostaining was found in the endothelial layer of all arteries and arterioles of kidney cortex and in some descending vasa recta. CE-positive reactions were also seen in most glomeruli, the reaction product being confined to only a few capillary loops in connection with the glomerular stalk. A few immunostained capillaries in the cortical labyrinth were suspected to belong to the first ramifications of the efferent arteriole. The bulk of all other of the glomerular and peritubula capillaries as well as all veins of the kidney showed no obvious immunostaining. The functional significance of this specific localization pattern of CE in the endothelium of kidney vessels is discussed with respect to the actions of the systemic and the local, intrarenal renin-angiotensin-system on kidney functions.
一种针对纯兔肺转化酶（CE）的抗体，该抗体与其他物种的CE存在交叉反应，被用于大鼠肾脏的免疫细胞化学研究。采用间接标记PAP技术，在肾皮质所有动脉和小动脉的内皮层以及一些直小血管降支中发现了特异性免疫染色。在大多数肾小球中也可见CE阳性反应，反应产物仅局限于与肾小球柄相连的少数毛细血管袢。皮质迷路中的一些免疫染色毛细血管被怀疑属于出球小动脉的第一级分支。肾脏的所有其他肾小球和肾小管周围毛细血管以及所有静脉均未显示明显的免疫染色。结合全身和局部肾内肾素-血管紧张素系统对肾脏功能的作用，讨论了CE在肾血管内皮中这种特异性定位模式的功能意义。
