[Long-term examinations of fundic mucosa in gastroduodenal ulcer after SpV and pyloroplasty (author's transl)].

Morphological examinations of the fundic mucosa with quantitative analysis of the parietal, chief and mucous neck cells were carried out with duodenal ulcer cases before selective proximal vagotomy and pyloroplasty, and over a period of more than four years after the operation. In the material removed by forceps biopsy from 15 duodenal ulcer cases, an early post-operative parietal cell density reduction of 74.15% was found, and from 5 gastric ulcer cases a reduction of 73.77%. This result occurred over an examination period of four years. The post-operative displacement in the distribution of the parietal cell within the fundic gland was pointed out, as well as the increased post-operative inflammatory indurating changes in the fundic mucosa, which occur only in gastric ulcer cases. The thickness of the mucosa was measured with an ocular micrometer pre- and post-operatively in 8 cases, and a post-operative reduction of about 20% was found. The relationshiop between the degree of post-operative parietal cell reduction and the insulin-stimulated acid-secretion was checked and no significant difference between the absolutely insulin-negative and insulin-positive groups was found post-operatively. To supplement these findings, the reaction of the succinatdehydrogenase activity in the mitochondria of the parietal cell was analysed semiquantitatively and by absorption-photometer. Thus a post-operative reduction of enzyme-activity of 20.45% on average was found in duodenal ulcer cases. In gastric ulcer cases there was no evidence of any reduction.