Roland M
Scand J Gastroenterol. 1976;11(1):65-71.
In 10 patients with duodenal ulcer gastric secretion was studied after graded doses of pentagastrin before and 3 months after truncal vagotomy and pyloroplasty. In 6 patients carbacholine was also infused simultaneously with the greatest dose of pentagastrin after vagotomy. The histology of the gastric mucosa was studied in suction biopsies obtained from the corpus of the stomach before and 3 months after the operation. After truncal vagotomy with pyloroplasty the maximal pentagastrin-stimulated acid and pepsin secretion and the sensitivity of the parietal cells to pentagastrin were all reduced significantly. There was no significant increase in maximal pentagastrin-stimulated acid and pepsin secretion when carbacholine was added to pentagastrin. The average thickness of the gastric mucosa and the mean number of parietal cells per unit area of the stomach did not show any significant change, while the number of patients with deep gastritis increased significantly after vagotomy.
对10例十二指肠溃疡患者在进行迷走神经干切断术和幽门成形术前及术后3个月，给予不同剂量的五肽胃泌素后研究胃分泌情况。6例患者在迷走神经切断术后，还在给予最大剂量五肽胃泌素的同时静脉滴注卡巴胆碱。在手术前及术后3个月，从胃体获取吸引活检组织，研究胃黏膜的组织学情况。迷走神经干切断术加幽门成形术后，五肽胃泌素刺激后的最大胃酸和胃蛋白酶分泌以及壁细胞对五肽胃泌素的敏感性均显著降低。当在五肽胃泌素中加入卡巴胆碱时，五肽胃泌素刺激后的最大胃酸和胃蛋白酶分泌没有显著增加。胃黏膜的平均厚度和胃单位面积壁细胞的平均数没有显示出任何显著变化，而迷走神经切断术后患重度胃炎的患者数量显著增加。
