Tsuchiya J, Murakami H, Okamoto K, Nemoto K, Omine M, Maekawa T
Jpn J Antibiot. 1982 May;35(5):1167-71.
Clinical investigation of cefotiam and aminoglycosides combination use against infections complicated by acute leukemia was performed, and the results obtained were as follows. 1) Sixteen patients were treated with cefotiam in doses 4--6 grams per day parenterally. The clinical effectiveness were excellent 47.6%, good 14.3%, fair 9.5% and poor 28.6%. No significant differences in therapeutic efficacy was observed between the patients given CTM 4 g/day and CTM 6 g/day. 2) It was considered that the clinical effectiveness of CTM has not been influenced by the difference of a number of maturation granulocyte. CTM has showed a certain, though not distinctive, efficacy compared with CFX. 3) As side effects with CTM, eruption appeared in 1 case, and no remarkable laboratory findings was observed. Cefotiam is thus considered to be a useful drug for the treatment of infections complicated by acute leukemia.
对头孢替安与氨基糖苷类药物联合用于治疗急性白血病合并感染进行了临床研究，结果如下。1）16例患者接受头孢替安治疗，静脉给药剂量为每日4 - 6克。临床有效率为：优47.6%，良14.3%，中9.5%，差28.6%。给予每日4克头孢替安的患者与给予每日6克头孢替安的患者在治疗效果上未观察到显著差异。2）认为头孢替安的临床疗效未受成熟粒细胞数量差异的影响。与头孢呋辛相比，头孢替安显示出一定疗效，但不显著。3）头孢替安的副作用方面，有1例出现皮疹，未观察到明显的实验室检查异常。因此，头孢替安被认为是治疗急性白血病合并感染的一种有效药物。
