普萘洛尔和地尔硫䓬对豚鼠颈上神经节神经节传递的频率依赖性抑制作用
Frequency-dependent depression of ganglionic transmission by propranolol and diltiazem in the superior cervical ganglion of the guinea-pig.
作者信息
Ito H, Nishi K
出版信息
Br J Pharmacol. 1982 Oct;77(2):359-62. doi: 10.1111/j.1476-5381.1982.tb09305.x.
Abstract
1 Effects of propranolol and diltiazem on ganglionic transmission in the superior cervical ganglion of the guinea-pig were investigated with intracellular recording techniques. 2 Propranolol and diltiazem (5 X 10(-6)-10(-5) M) induced a transmission failure in the ganglion upon preganglionic nerve stimulation at high frequency (25-30 Hz) without affecting action potentials induced by direct stimulation of the soma membrane, or potentials induced by iontophoretically applied acetylecholine. 3 The results suggest that propranolol and diltiazem may act on preganglionic nerve terminals to inhibit Ca2+ influx in a frequency-dependent manner. These agents may depress excess sympathetic activity without much affecting normal ganglionic transmission.
摘要
- 采用细胞内记录技术，研究了普萘洛尔和地尔硫䓬对豚鼠颈上神经节神经节传递的影响。2. 普萘洛尔和地尔硫䓬（5×10⁻⁶ - 10⁻⁵ M）在高频（25 - 30 Hz）刺激节前神经时，可导致神经节传递失败，而不影响直接刺激胞体膜所诱发的动作电位，或离子透入法施加乙酰胆碱所诱发的电位。3. 结果表明，普萘洛尔和地尔硫䓬可能作用于节前神经末梢，以频率依赖性方式抑制Ca²⁺内流。这些药物可能抑制过度的交感神经活动，而对正常的神经节传递影响不大。
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本文引用的文献
1
THE ACTION OF CATECHOLAMINES IN SYMPATHETIC GANGLIA.儿茶酚胺在交感神经节中的作用。
Can J Biochem Physiol. 1963 Dec;41:2627-36.
2
Intracellular potentials recorded from a mammalian sympathetic ganglion.从哺乳动物交感神经节记录的细胞内电位。
J Physiol. 1955 Dec 29;130(3):572-84. doi: 10.1113/jphysiol.1955.sp005428.
3
The electrical properties of crustacean muscle fibres.甲壳类动物肌肉纤维的电特性。
J Physiol. 1953 Apr 28;120(1-2):171-204. doi: 10.1113/jphysiol.1953.sp004884.
4
Diltiazem actions on smooth muscle cells of the porcine coronary artery and on neuromuscular junctions of the guinea-pig vas deferens.地尔硫䓬对猪冠状动脉平滑肌细胞及豚鼠输精管神经肌肉接头的作用。
Gen Pharmacol. 1980;11(6):561-8. doi: 10.1016/0306-3623(80)90091-9.
5
Actions of verapamil, diltiazem and other divalent cations on the calcium-current of Helix neurones.维拉帕米、地尔硫䓬及其他二价阳离子对缢蛏神经元钙电流的作用。
Br J Pharmacol. 1981 Sep;74(1):87-95. doi: 10.1111/j.1476-5381.1981.tb09958.x.
6
Further analysis of inhibitory effects of propranolol and local anaesthetics on the calcium current in Helix neurones.普萘洛尔和局部麻醉药对河蜗神经元钙电流抑制作用的进一步分析。
Br J Pharmacol. 1982 May;76(1):37-43. doi: 10.1111/j.1476-5381.1982.tb09188.x.
7
Inhibitory effects of propranolol on the calcium current of Helix neurones.普萘洛尔对螺旋神经元钙电流的抑制作用。
Br J Pharmacol. 1981 Jun;73(2):431-4. doi: 10.1111/j.1476-5381.1981.tb10439.x.
8
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J Mol Cell Cardiol. 1980 Jun;12(6):635-8. doi: 10.1016/0022-2828(80)90020-6.
9
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Jpn J Pharmacol. 1980 Oct;30(5):607-19. doi: 10.1254/jjp.30.607.
10
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J Physiol. 1968 Nov;199(1):189-203. doi: 10.1113/jphysiol.1968.sp008648.
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