Jelinek J E
J Am Acad Dermatol. 1982 Oct;7(4):526-40. doi: 10.1016/s0190-9622(82)70135-5.
Many tumors of the skin, whether originating from ectoderm or mesoderm, exist in either single or multiple form. In the multiple state there are frequently associations with other cutaneous and systemic abnormalities, sometimes serious and even life-threatening. The resultant syndrome is almost always inherited in an autosomal dominant pattern. By contrast, solitary lesions are not heritable, nor are they associated with other stigmata. The solitary forms appear in middle or late life, the multiple, syndromic forms in childhood or early adulthood.
许多皮肤肿瘤，无论起源于外胚层还是中胚层，都以单发或多发形式存在。在多发状态下，常与其他皮肤和全身异常相关，有时情况严重甚至危及生命。由此产生的综合征几乎总是以常染色体显性模式遗传。相比之下，孤立性损害不具有遗传性，也不与其他体征相关。孤立性损害出现在中年或晚年，而多发性、综合征性损害则出现在儿童期或成年早期。
