Deseda-Tous J, Cherry J D, Spencer M J, Welliver R C, Boyer K M, Dudley J P, Zahradnik J M, Krause P J, Walbergh E W
Am J Dis Child. 1978 Mar;132(3):287-90. doi: 10.1001/archpedi.1978.02120280071015.
During a measles immunization campaign 203 children were enrolled in an antibody response study. Of this group, follow-up clinical data and sera samples were available from 125 children three weeks after immunization and from 90 children ten months later. Seventy-six of the children had been previously vaccinated, ten had a history of measles and 39 denied vaccination or illness. Twenty-six of the children had prevaccination hemagglutination inhibiting antibody titers of less than 5. Of this group 12 had a primary immune response (IgM measles antibody) with geometric mean titers (GMT) of 90 and 40 three weeks and ten months respectively after vaccination. In contrast, the other 14 children with initial titers of less than 5 had secondary immune responses (only IgG measles antibody) with GMTs of 28 and 9 three weeks and ten months after vaccination. Since the antibody responses in these children who had previously been stimulated by measles antigen were modest and transient, it is suggested that booster immunization may not be effective in preventing future secondary vaccine failures. Also noted in this study was a poor correlation between historical data and actual measles antibody.
在一次麻疹免疫活动期间，203名儿童参与了一项抗体反应研究。在该组儿童中，免疫接种三周后可获得125名儿童的随访临床数据和血清样本，十个月后可获得90名儿童的相关数据。其中76名儿童此前已接种过疫苗，10名有麻疹病史，39名否认接种过疫苗或患过病。26名儿童接种前血凝抑制抗体滴度低于5。在这一组中，12名儿童出现了初次免疫反应（麻疹IgM抗体），接种疫苗三周和十个月后的几何平均滴度（GMT）分别为90和40。相比之下，其他14名初始滴度低于5的儿童出现了二次免疫反应（仅麻疹IgG抗体），接种疫苗三周和十个月后的GMT分别为28和9。由于这些先前受到麻疹抗原刺激的儿童的抗体反应较弱且短暂，因此有人认为加强免疫可能无法有效预防未来的二次疫苗接种失败。该研究还指出，既往数据与实际麻疹抗体之间的相关性较差。
