Hays S E, Paul S M
Life Sci. 1982 Jul 26;31(4):319-22. doi: 10.1016/0024-3205(82)90409-x.
Cholecystokinin (CCK) receptor binding was measured in postmortem brain tissue of patients with Alzheimer's dementia, Huntington's chorea, and neurologically healthy matched controls. CCK binding was significantly reduced inthe basal ganglia and cerebral cortex of Huntington's patients, but was normal in the temporal and cingulate cortex of patients with Alzheimer's disease. These findings indicate that CCK receptor loss is unique to specific neurodegenerative disease(s), and that CCK may be involved in the symptoms of Huntington's disease but is not implicated in the neuropathology of Alzheimer's dementia.
在患有阿尔茨海默病性痴呆、亨廷顿舞蹈症的患者以及与之匹配的神经功能正常的对照者的死后脑组织中，检测了胆囊收缩素（CCK）受体结合情况。亨廷顿病患者的基底神经节和大脑皮质中的CCK结合显著减少，但阿尔茨海默病患者的颞叶和扣带回皮质中的CCK结合正常。这些发现表明，CCK受体丧失是特定神经退行性疾病所特有的，并且CCK可能与亨廷顿病的症状有关，但与阿尔茨海默病性痴呆的神经病理学无关。
