前列腺素对绵羊胎盘循环的血管收缩作用。

Vasoconstrictive effects of prostaglandins in sheep placental circulations.

作者信息

McLaughlin M K, Brennan S C, Chez R A

出版信息

Am J Obstet Gynecol. 1978 Feb 15;130(4):408-13. doi: 10.1016/0002-9378(78)90281-8.

Abstract

Changes in the uterine and umbilical circulations after intra-aortic injection of prostaglandin E2 (PGE2) or protaglandin F2alpha (PGF2alpha) to either the fetus or the mother have been examined in 13 ewes at late gestation. PGF2alpha vien to either the fetus or the mother is vasoconstrictive in both uterine and umbilical circulations. PGE2 given to the fetus results in a dissociated response with vasodilation of the uterine circulation and vasoconstriction of the umbilical circulation. PGE2 given to the mother causes a uterine contraction that precludes specific hemodynamic analysis. Therefore, exposure of either maternal or fetal ovine circulation to exogenous prostaglandins in associated with acute changes in both placental circulations. Similar responses to pertubations in endogenous prostaglandin levels may exist in pregnant sheep.

摘要

在13只妊娠晚期的母羊中，研究了向胎儿或母体主动脉内注射前列腺素E2（PGE2）或前列腺素F2α（PGF2α）后子宫和脐循环的变化。向胎儿或母体注射PGF2α会使子宫和脐循环血管收缩。给胎儿注射PGE2会导致分离反应，子宫循环血管舒张而脐循环血管收缩。给母体注射PGE2会引起子宫收缩，从而无法进行特定的血流动力学分析。因此，母体或胎儿羊的循环系统暴露于外源性前列腺素会导致胎盘循环的急性变化。妊娠绵羊对内源性前列腺素水平变化可能也有类似反应。