一些肾上腺素能β受体阻滞剂在体外对人体脂肪组织的脂解作用有影响。
Some adrenergic beta-blocking agents affecting lipolysis in human adipose tissue in vitro.
作者信息
Wenkeová J, Kuhn E, Wenke M
出版信息
Eur J Pharmacol. 1976 May;37(1):91-5. doi: 10.1016/0014-2999(76)90011-x.
PMID:6293
Abstract
Antagonistic actions of beta-blocking drugs on isoproterenol-induced lipolysis were studied in human omental adipose tissue. Competitive interaciton characterized by the following pA2 values was found: propranolol 8.7; trimepranol 8.7; practolol 7.1; H 35/25 6.0. The plot of pA2 values of these drugs for human versus rat adipose tissue is linear with slope 2.0 indicating a higher differentiation of beta-antagonist actions in human than in rat adipose tissue.
摘要
在人网膜脂肪组织中研究了β受体阻滞剂对异丙肾上腺素诱导的脂肪分解的拮抗作用。发现了以以下pA2值为特征的竞争性相互作用：普萘洛尔8.7；三甲丙咪嗪8.7；普拉洛尔7.1；H 35/25 6.0。这些药物在人脂肪组织与大鼠脂肪组织中的pA2值曲线呈线性，斜率为2.0，表明β受体拮抗剂在人脂肪组织中的作用比在大鼠脂肪组织中具有更高的特异性。
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