心脏选择性β-肾上腺素能受体阻滞剂对人和大鼠脂肪细胞的异丙肾上腺素拮抗作用。
Isoprenaline antagonism of cardioselective beta-adrenergic receptor blocking agents on human and rat adipocytes.
作者信息
Harms H H, Van der Meer J
出版信息
Br J Clin Pharmacol. 1975 Aug;2(4):311-5. doi: 10.1111/j.1365-2125.1975.tb02776.x.
Abstract
- The beta-adrenergic blocking potencies of practolol, ICI 66082, tolamolol, acebutolol, H 93/26, H 87/07, pindolol and Ro 3-4787 were compared with that of propranolol, on human and rat adipocytes. 2. A good correlation was found between the potencies on adipocytes of the two species but not between our results and literature data on antagonism of isopernaline tachycardia in the anaesthetized cat. 3. The results indicate that differences between adrenergic beta-receptors in heart and adipose tissue may be detected using cardioselective beta-adrenergic receptor blocking agents.
摘要
- 在人和大鼠脂肪细胞上，比较了心得宁、ICI 66082、托拉洛尔、醋丁洛尔、H 93/26、H 87/07、吲哚洛尔和Ro 3 - 4787与普萘洛尔的β-肾上腺素能阻断效能。2. 发现这两种物种脂肪细胞上的效能之间存在良好的相关性，但我们的结果与麻醉猫中异丙肾上腺素性心动过速拮抗作用的文献数据之间不存在相关性。3. 结果表明，使用心脏选择性β-肾上腺素能受体阻断剂可以检测心脏和脂肪组织中肾上腺素能β受体之间的差异。
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