Pilotti S, Rilke F, Gribaudi G, Ravasi G L
Acta Cytol. 1982 Sep-Oct;26(5):649-54.
Of 400 consecutive patients with histologically proven carcinoma of the lung, one to six sputum samples (mean, 2.8) were examined cytologically; 60% also had histologic examination of paraffin-embedded material. The overall sensitivity of sputum cytology was 0.58. The sensitivity increased from 0.37 to 0.57 when three samples rather than one were examined; it increased by only another 0.01 when four to six samples were studied. The examination of paraffin-embedded material yielded another 0.075 increase in sensitivity. A multiparametric study, including diameter, cavitation, site and histologic type of the pulmonary tumors, showed that sputum cytology was particularly significant for neoplasms of the left upper lobe and that the sensitivity related to the histologic type was not independent of the site, diameter and cavitation. The overall cytologic typing accuracy was 0.77, with a range from 0.20 to 0.96. The majority of the diagnoses at variance with histology and the unclassified malignant epithelial tumor cells were found to be associated predominantly with carcinoma of the large-cell type and with poorly differentiated adenocarcinomas.
在400例经组织学证实为肺癌的连续患者中，对1至6份痰标本（平均2.8份）进行了细胞学检查；60%的患者还对石蜡包埋材料进行了组织学检查。痰细胞学检查的总体敏感性为0.58。当检查三份标本而非一份时，敏感性从0.37提高到0.57；当研究四至六份标本时，敏感性仅再提高0.01。对石蜡包埋材料的检查使敏感性又提高了0.075。一项多参数研究，包括肺肿瘤的直径、空洞形成、部位和组织学类型，显示痰细胞学检查对左上叶肿瘤尤为重要，且与组织学类型相关的敏感性并非独立于部位、直径和空洞形成。总体细胞学分型准确率为0.77，范围为0.20至0.96。发现大多数与组织学不符的诊断以及未分类的恶性上皮肿瘤细胞主要与大细胞型癌和低分化腺癌有关。
