Shaklai M, Tavassoli M
Am J Pathol. 1978 Mar;90(3):633-44.
This study is an ultrastructural analysis of hemopoiesis in S1/S1d anemic mice. The anemia in this strain is caused by a defect in hemopoietic microenvironment which fails to support hemopoiesis. Marrow cellularity is reduced and vascular channels are dilated. Coverage of sinus endothelium by adventitial cells is nearly twice as in normal mice, suggesting a reduced rate of cell traffic into the circulation. Central macrophages are small with little or no interdigitation with erythroid cells and no crystalloid inclusions as seen in normal littermates. The findings suggest that a fundamental abnormality in the central macrophage may be responsible for the defect in hemopoietic microenvironment.
本研究是对S1/S1d贫血小鼠造血的超微结构分析。该品系的贫血是由造血微环境缺陷所致，这种缺陷无法支持造血。骨髓细胞密度降低，血管通道扩张。外膜细胞对窦内皮的覆盖几乎是正常小鼠的两倍，这表明细胞进入循环的速率降低。中央巨噬细胞较小，与红系细胞很少或没有相互交错，且没有正常同窝小鼠中所见的晶体包涵体。这些发现表明，中央巨噬细胞的基本异常可能是造血微环境缺陷的原因。
