Lindholm C E, Kjellén E, Landberg T, Nilsson P, Persson B
Acta Radiol Oncol. 1982;21(4):241-54. doi: 10.3109/02841868209134013.
The combination of microwave-induced (2450 MHz) hyperthermia and ionizing radiation was used in 7 patients with superficial malignant tumours, which were considered refractory to other therapy. A newly developed heating system was used, allowing for a maintained temperature at the master probe of 42.5 degrees C +/- 0.5 degrees C during 45 min, but temperature measurements at multiple sites showed a marked variation. This preliminary series indicates that the combination of hyperthermia and ionizing radiation may be useful, the response rate (complete or partial) being 8 of 8 evaluable lesions. Even previously heavily irradiated sites responded. Technical improvements are highly needed to allow for controlled heating of any tissue volume.
微波诱导（2450兆赫）热疗与电离辐射相结合，应用于7例浅表恶性肿瘤患者，这些肿瘤被认为对其他治疗无效。使用了一种新开发的加热系统，在45分钟内可使主探头的温度维持在42.5摄氏度±0.5摄氏度，但多个部位的温度测量显示存在明显差异。这个初步系列表明，热疗与电离辐射相结合可能有用，8个可评估病变中有8个出现反应（完全或部分反应）。即使是先前接受过大量放疗的部位也有反应。迫切需要技术改进，以便能对任何组织体积进行可控加热。
