Ribeiro A B, Krakoff L R
Am J Physiol. 1978 Mar;234(3):E267-72. doi: 10.1152/ajpendo.1978.234.3.E267.
The effect of total adrenalectomy on the mechanisms of arterial pressure control was studied in uninephrectomized rats with and without renal artery stenosis (Goldblatt one-kidney model). Four groups of rats were prepared and maintained on high-salt intake (1% NaCl): uninephrectomized-KI; KI + adrenalectomy-KIAx; uninephrectomized with renal artery stenosis-GI; and GI with adrenalectomy-GIAx. Over 3 wk blood pressure rose significantly in both GI and GIAx but the degree of increase in GI was greater. Hyponatremia, hyperkalemia, and increased plasma urea nitrogen were observed in both KIAx and GIAx. Plasma renin concentration (PRC) and plasma renine activity (PRA) were markedly increased and plasma renin substrate (PRS) was decreased in both adrenalectomized groups. Infusion of saralasin resulted in significant and similar reductions in mean arterial pressure (MAP) in KIAx and GIAx, but had no effect on MAP in KI and GI. These results allow approximations of the contribution to total MAP of identifiable components, which are: the total adrenal component, the renin-angiotensin system component, which partially compensates for loss of the adrenal secretions, and the independent effect of the renal artery clip. Thus, a multifactorial analysis of GI hypertension is provided.
在单侧肾切除且伴有或不伴有肾动脉狭窄（戈德布拉特单肾模型）的大鼠中，研究了双侧肾上腺切除对动脉血压控制机制的影响。制备了四组大鼠，并维持高盐摄入（1%氯化钠）：单侧肾切除-KI；KI+双侧肾上腺切除-KIAx；单侧肾切除伴肾动脉狭窄-GI；以及GI+双侧肾上腺切除-GIAx。在3周多的时间里，GI和GIAx两组的血压均显著升高，但GI组的升高幅度更大。在KIAx和GIAx两组中均观察到低钠血症、高钾血症和血浆尿素氮升高。在两个双侧肾上腺切除组中，血浆肾素浓度（PRC）和血浆肾素活性（PRA）均显著升高，而血浆肾素底物（PRS）降低。静脉注射沙拉新导致KIAx和GIAx两组的平均动脉压（MAP）显著且相似地降低，但对KI和GI两组的MAP没有影响。这些结果有助于估算可识别成分对总MAP的贡献，这些成分包括：双侧肾上腺成分、部分补偿肾上腺分泌丧失的肾素-血管紧张素系统成分，以及肾动脉夹闭的独立作用。因此，提供了对GI高血压的多因素分析。
