蛋白水解激活可产生一种对Ca2+高度敏感的磷脂酰肌醇磷酸二酯酶。
Proteolytic activation can produce a phosphatidylinositol phosphodiesterase highly sensitive to Ca2+.
作者信息
Hirasawa K, Irvine R F, Dawson R M
出版信息
Biochem J. 1982 Sep 15;206(3):675-8. doi: 10.1042/bj2060675.
Abstract
The phosphatidylinositol phosphodiesterase of rat brain shows little activity under conditions likely to pertain in vivo (neutral pH and micromolar Ca(2+) concentrations). A short incubation of a brain supernatant with trypsin, or a longer pre-incubation of the supernatant alone, produce new forms of the enzyme, which are active under such conditions. A possible role of receptor-linked proteinases in initiating phosphatidylinositol catabolism is discussed.
摘要
大鼠脑的磷脂酰肌醇磷酸二酯酶在可能与体内情况相关的条件下（中性pH值和微摩尔钙浓度）活性很低。将脑匀浆上清液与胰蛋白酶短时间孵育，或仅将上清液长时间预孵育，会产生该酶的新形式，这些新形式在上述条件下具有活性。本文讨论了受体相关蛋白酶在启动磷脂酰肌醇分解代谢中可能发挥的作用。
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