钙离子对大鼠前脑甘油磷酸胆碱磷酸二酯酶的激活作用。
Activation of glycerophosphocholine phosphodiesterase in rat forebrain by Ca2+.
作者信息
Spanner S, Ansell G B
出版信息
Biochem J. 1982 Dec 15;208(3):845-50. doi: 10.1042/bj2080845.
Abstract
The highest activity of glycerophosphocholine phosphodiesterase (EC 3.1.4.2) in subcellular fractions of rat forebrain was found in the microsomal fraction though significant amounts were found in fractions containing plasma membranes. With the use of Ca(2+)/EGTA and Ca(2+)/EDTA buffers it was shown that very low concentrations of free Ca(2+) (EC(50)approx. 10(-9)m) could activate the enzyme.
摘要
在大鼠前脑亚细胞组分中，甘油磷酸胆碱磷酸二酯酶（EC 3.1.4.2）的最高活性存在于微粒体组分中，不过在含有质膜的组分中也发现了大量该酶。使用Ca(2+)/EGTA和Ca(2+)/EDTA缓冲液表明，极低浓度的游离Ca(2+)（EC(50)约为10(-9)m）就能激活该酶。
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
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J Reprod Fertil. 1965 Apr;9:163-76. doi: 10.1530/jrf.0.0090163.
3
Glycerylphosphorylcholine diesterase activity of nervous tissue.神经组织的甘油磷酸胆碱二酯酶活性
Biochem J. 1957 Feb;65(2):374-7. doi: 10.1042/bj0650374.
4
Applications of metal buffers and metal indicators in biochemistry.金属缓冲剂和金属指示剂在生物化学中的应用。
Methods Biochem Anal. 1956;3:301-25. doi: 10.1002/9780470110195.ch10.
5
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