Holle J P, Heisler N, Scheid P
Am J Physiol. 1978 Mar;234(3):R146-54. doi: 10.1152/ajpregu.1978.234.3.R146.
Blood flow to subunits of the lung was studied in the duck by use of radioactive microspheres. In spontaneously breathing, unanesthetized animals (series I) neopulmo was slightly better perfused than the average lung and along the paleopulmonic parabronchi, blood flow was found to decrease in the direction of ventilatory gas flow and thus of decreasing PO2 and increasing PCO2 in lung gas. The effects of respiratory gases on regional lung perfusion were investigated in unidirectionally ventilated animals (series II) in which gas mixtures offered to both lungs could be controlled independently. Local hypoxia resulted in reduction of local blood flow, whereas effects from hyperoxia or CO2 could not be substantiated. Reversal of the direction of unidirectional ventilatory flow (series III), and thus reversal of the profiles of respired gas concentrations along the parabronchi, suggest that the inhomogeneity in blood flow observed in spontaneously breathing animals of series I can only in part be explained as an acute adjustment to the local hypoxia. Calculations show that this inhomogeneity of blood flow constitutes an only minor impairment of the overall gas exchange efficacy of the parabronchial lung.
利用放射性微球研究了鸭肺亚单位的血流情况。在自主呼吸、未麻醉的动物（系列I）中，新肺灌注略优于平均肺灌注，并且沿着古肺支气管，发现血流在通气气流方向上减少，从而导致肺内气体的PO2降低和PCO2升高。在单向通气的动物（系列II）中研究了呼吸气体对局部肺灌注的影响，在这些动物中，提供给双肺的气体混合物可以独立控制。局部缺氧导致局部血流减少，而高氧或二氧化碳的影响无法得到证实。单向通气气流方向的逆转（系列III），以及因此沿支气管呼吸气体浓度分布的逆转，表明在系列I的自主呼吸动物中观察到的血流不均匀性只能部分解释为对局部缺氧的急性适应。计算表明，这种血流不均匀性对支气管肺整体气体交换效率的损害很小。
