肺泡细胞癌：痰细胞诊断中的一个问题。

Spriggs A I, Cole M, Dunnill M S

J Clin Pathol. 1982 Dec;35(12):1370-9. doi: 10.1136/jcp.35.12.1370.

Cytology and histology are correlated in a series of 22 cases chosen to illustrate the differential diagnosis between clusters of benign bronchial or bronchiolar cells seen in sputum, and those of alveolar cell carcinoma or adenocarcinoma with alveolar spread. Alveolar-cell carcinoma is characterised by clusters of small epithelial cells in spherical or irregular formations, none showing enough polarity to distinguish a smooth or palisaded surface. The appearances are most distinctive if vacuolation is absent. The diagnosis cannot, however, be confidently made in all cases from morphological features of cells in sputum.

选取了22例病例，对痰中所见良性支气管或细支气管细胞团与肺泡细胞癌或伴有肺泡播散的腺癌进行鉴别诊断，分析了细胞学与组织学的相关性。肺泡细胞癌的特征是小上皮细胞团呈球形或不规则形，没有一个细胞团显示出足够的极性以区分出光滑或栅栏状表面。如果没有空泡形成，其表现最为独特。然而，不能仅凭痰中细胞的形态特征在所有病例中都做出可靠诊断。