Piecuch J F
J Dent Res. 1982 Dec;61(12):1458-60. doi: 10.1177/00220345820610121801.
Coralline replamineform hydroxyapatite implants were placed in canine subcutaneous tissues in an attempt to clarify whether the hydroxyapatite matrix acted as a passive matrix for osseous ingrowth when placed in some inherent bone induction capacity. The implants were well-tolerated and elicited no deleterious host response. Connective tissue rapidly infiltrated the pores, but no evidence of bone formation was noted in any of the specimens. It was concluded that this implant material does not act to induce bone formation.
将珊瑚状复制型羟基磷灰石植入物置于犬皮下组织中，旨在明确当置于具有一定固有骨诱导能力时，羟基磷灰石基质是否作为骨向内生长的被动基质。植入物耐受性良好，未引发有害的宿主反应。结缔组织迅速渗入孔隙，但在任何标本中均未发现骨形成的证据。得出的结论是，这种植入材料不会诱导骨形成。
