年龄对健康男性红细胞膜钠钾依赖性三磷酸腺苷酶（Na+-K+ ATP酶）活性的影响。

Effect of age on red cell membrane sodium -potassium dependent adenosine triphosphatase (Na+-K+ ATPase) activity in healthy men.

作者信息

Gambert S R, Duthie E H

出版信息

J Gerontol. 1983 Jan;38(1):23-5. doi: 10.1093/geronj/38.1.23.

DOI:10.1093/geronj/38.1.23

Abstract

Decreased cellular thermogenesis may represent a normal aspect of the aging process. Whereas Na+-K+ ATPase appears to be involved directly in body metabolism, enzyme activity on the erythrocyte membrane Na+-K+ ATPase was significantly lower in aged men. In a separate series of experiments, each with representation from the two age groups, red cell membrane Na+-K+ ATPase was also found to be decreased significantly in the aged men. Although mean values were statistically different, one of the elderly men had enzyme activity above that of the mean of the younger men. None of the younger men had enzyme activity below the mean of the older group. Red cell membrane Na+-,+ ATPase activity may be an indicator of physiological aging.

摘要

细胞产热减少可能是衰老过程的一个正常方面。鉴于钠钾ATP酶似乎直接参与身体代谢，老年男性红细胞膜上的钠钾ATP酶活性显著降低。在另一系列实验中，每个实验都有两个年龄组的代表参与，结果发现老年男性的红细胞膜钠钾ATP酶也显著降低。虽然平均值在统计学上有差异，但有一位老年男性的酶活性高于年轻男性的平均值。没有一位年轻男性的酶活性低于老年组的平均值。红细胞膜钠钾ATP酶活性可能是生理衰老的一个指标。