Nanri S, Akita H, Jozaki K, Iwata S, Iwasaki Y, Tojo M, Hotta M, Yamashita N, Sunakawa K, Oikawa T, Osano M, Ichihashi Y, Ishikawa K, Kanemitsu T, Ri S, Shirane K, Kanki K, Kawai S, Saito N
Jpn J Antibiot. 1982 Jul;35(7):1749-60.
Cefotaxime (CTX) was used in the treatment and prophylaxis of infections in neonates and immature infants. The following results were obtained. 1. Mean serum concentrations (bioassay) 30 minutes after a single intravenous injection of about 20 mg/kg of CTX were 44.5 mcg/ml in neonates and 47.2 mcg/ml in immature infants aged 0-3 days, 45.8 mcg/ml in neonates and 56.4 mcg/ml in an immature infant aged 4-7 days and 40.6 mcg/ml in neonates and 38.1 mcg/ml in immature infants aged 8 or more days. Six hour values were respectively 10.9 mcg/ml, 17.0 mcg/ml, 4.6 mcg/ml, 13.4 mcg/ml, 3.8 mcg/ml and 2.7 mcg/ml. 2. Mean serum concentration half-lives were 3.0 hours in neonates and 3.2 hours in immature infants aged 0-3 days, 1.8 hours in neonates and 3.2 hours in an immature infant aged 4-7 days, and 1.5 hours in neonates and 1.6 hours in immature infants aged 8 or more days. 3. Urinary recovery rates were 0.8-78.0% for 0-6 hours after treatment. 4. Adequate clinical efficacy can be expected by the intravenous injection of CTX in doses of 20 mg/kg 2 times daily, every 12 hours, in neonates and immature infants aged 0-3 days, 20 mg/kg 3 times daily, every 8 hours, in neonates and immature infants aged 4-7 days, and 20 mg/kg 3 to 4 times daily, every 6-8 hours, in neonates and immature infants aged 8 or more days. 5. The clinical efficacy of CTX was good in all 4 cases of sepsis (including suspected case), excellent in 1 case of urinary tract infection, and good in all 4 cases of fever of unknown origin for a cure rate of 100%. 6. Adverse reactions were not noted in any cases.
头孢噻肟（CTX）用于新生儿和未成熟儿感染的治疗及预防。获得了以下结果。1. 单次静脉注射约20mg/kg CTX后30分钟的平均血清浓度（生物测定法），新生儿为44.5mcg/ml，0至3日龄未成熟儿为47.2mcg/ml；4至7日龄未成熟儿为56.4mcg/ml，新生儿为45.8mcg/ml；8日龄及以上未成熟儿为38.1mcg/ml，新生儿为40.6mcg/ml。6小时的值分别为10.9mcg/ml、17.0mcg/ml、4.6mcg/ml、13.4mcg/ml、3.8mcg/ml和2.7mcg/ml。2. 平均血清浓度半衰期，新生儿为3.0小时，0至3日龄未成熟儿为3.2小时；4至7日龄未成熟儿为3.2小时，新生儿为1.8小时；8日龄及以上未成熟儿为1.6小时，新生儿为1.5小时。3. 治疗后0至6小时的尿回收率为0.8 - 78.0%。4. 对于0至3日龄的新生儿和未成熟儿，每12小时静脉注射20mg/kg CTX，每日2次；对于4至7日龄的新生儿和未成熟儿，每8小时静脉注射20mg/kg CTX，每日3次；对于8日龄及以上的新生儿和未成熟儿，每6至8小时静脉注射20mg/kg CTX，每日3至4次，可预期有足够的临床疗效。5. CTX对所有4例败血症（包括疑似病例）临床疗效良好，对1例尿路感染疗效极佳，对所有4例不明原因发热疗效良好，治愈率达100%。6. 未观察到任何不良反应。
