Takimoto M, Oka T, Yoshioka H, Sanae N, Maruyama S
Jpn J Antibiot. 1982 Jul;35(7):1816-8.
One full-term newborn infant and 2 premature ones were treated with cefotaxime for the treatment of suspected sepsis and umbilical suppurative inflammation. Pathogenic organisms could not be identified in all cases. A good result was obtained with the case of suspected sepsis. But the other 2 cases were not evaluable because underlying diseases such as massive pulmonary atelectasis or respiratory distress syndrome masked the effects of this agent. Serum levels of cefotaxime in 3 of the 4 cases were determined with bioassay. Time courses of the serum levels in 2 of them resulted in peculiar biphasic disappearance curves. This fact implies the possibility that desacetylation of cefroxime proceeds also in newborns as in adults and that desacetyl metabolite accumulates in the body owing to the premature function of the neonatal kidney.
1名足月儿和2名早产儿因疑似败血症和脐部化脓性炎症接受头孢噻肟治疗。所有病例均未鉴定出致病微生物。疑似败血症病例取得了良好效果。但另外2例无法评估，因为诸如大面积肺不张或呼吸窘迫综合征等基础疾病掩盖了该药物的效果。4例中的3例通过生物测定法测定了头孢噻肟的血清水平。其中2例的血清水平时间进程呈现出特殊的双相消失曲线。这一事实意味着头孢噻肟脱乙酰化在新生儿中也如在成人中一样会发生，并且由于新生儿肾脏功能不成熟，脱乙酰代谢产物会在体内蓄积。
