Brady P S, Brady L J, Ullrey D E, Romsos D R
Am J Vet Res. 1978 Feb;39(2):267-70.
Eight adult female Beagles were fasted for 21 days to investigate responses of the erythrocyte glutathione peroxidase system enzymes. Blood samples were collected once a week. Erythrocyte reduced glutathione was maintained within 10% of base-line value. Hexose monophosphate pathway dehydrogenases showed a significant inverse relationship to glutathione reductase (GR) activity. Further, active GR, as a percentage of total GR, increased as hexose monophosphate pathway dehydrogenase activity fell. A similar relationship between these enzymes has been reported in human glucose-6-phosphate dehydrogenase deficiency. Also, glutathione peroxidase showed an inverse linear response to erythrocytic reduced glutathione. Though the responses of this system are complex, they appear interrelated.
八只成年雌性比格犬禁食21天，以研究红细胞谷胱甘肽过氧化物酶系统酶的反应。每周采集一次血样。红细胞还原型谷胱甘肽维持在基线值的10%以内。磷酸己糖途径脱氢酶与谷胱甘肽还原酶（GR）活性呈显著负相关。此外，随着磷酸己糖途径脱氢酶活性下降，活性GR占总GR的百分比增加。在人类葡萄糖-6-磷酸脱氢酶缺乏症中也报道了这些酶之间的类似关系。此外，谷胱甘肽过氧化物酶对红细胞还原型谷胱甘肽呈线性负反应。虽然该系统的反应很复杂，但它们似乎相互关联。
