Dekoninck W J
Sem Hop. 1982 Oct 21;58(38):2223-9.
The most important aspects of normal and pathological brain ageing are considered from a structural, cellular, hemodynamical, chemical and clinical point of view. It seems admitted that cerebral blood flow and cerebral consumption for oxygen decrease with age but when severe health criteria are used to select normal old subjects, no significant differences exist between normal young and optimally healthy elderly. The question arises whether the blood flow reductions are responsible for the alterations in metabolism, or whether it is simply an autoregulatory response to the lesser metabolic demands of the tissue. The part of cerebral arteriosclerosis is questioned on cerebral flow drop accompanying clinical signs in senile mental impairment. Among some cardiovascular risk factors, hypertension seems to play a leading part in acute and chronic neurological diseases associated with age and with certain types of senile dementia (multi-infarct). However in all other cases, hypertension and cerebral vascular insufficiency, for all that this syndrome exists, seem to have been overestimated to explain chronic senile brain deterioration.
从结构、细胞、血液动力学、化学和临床角度考虑正常和病理性脑老化的最重要方面。似乎公认脑血流量和脑氧消耗量会随着年龄增长而下降，但当使用严格的健康标准来挑选正常老年受试者时，正常年轻人和健康状况最佳的老年人之间不存在显著差异。问题在于血流量减少是代谢改变的原因，还是仅仅是对组织较低代谢需求的一种自动调节反应。脑动脉硬化在老年精神障碍伴随临床症状的脑血流量下降中所起的作用受到质疑。在一些心血管危险因素中，高血压似乎在与年龄相关的急性和慢性神经疾病以及某些类型的老年性痴呆（多发梗死性）中起主导作用。然而在所有其他情况下，高血压和脑血管功能不全，尽管存在这种综合征，但似乎在解释慢性老年脑衰退方面被高估了。
