Johnson D H, Windham W W, Allen J H, Greco F A
AJR Am J Roentgenol. 1983 Jan;140(1):37-40. doi: 10.2214/ajr.140.1.37.
Computed tomography of the brain was performed as part of the initial staging evaluation of 84 patients with small cell lung cancer. Brain scans indicative of metastatic disease were obtained in 12 (14%) patients, two of whom had no neurologic signs or symptoms. One of these had no other extrathoracic disease. Brain scans without evidence of metastatic disease were obtained in 72 patients, 58 (80.5%) of whom had no signs or symptoms suggestive of metastatic intracranial disease. In the 14 patients with neurologic symptoms but negative computed tomographic scans, other explanations than brain metastases were found. It was concluded that head scanning is a sensitive and accurate method of detecting central nervous system metastases in patients with small cell lung cancer. However, head computed tomography should not be included as part of the initial staging evaluation of the neurologically asymptomatic patients. In only one of 60 such patients did the brain scan change the initial clinical staging, which included chest films, liver and bone scans, and bone marrow biopsy.
对84例小细胞肺癌患者进行了脑部计算机断层扫描，作为初始分期评估的一部分。12例（14%）患者的脑部扫描显示有转移性疾病，其中2例没有神经体征或症状。其中1例没有其他胸外疾病。72例患者的脑部扫描未发现转移性疾病证据，其中58例（80.5%）没有提示颅内转移性疾病的体征或症状。在14例有神经症状但计算机断层扫描阴性的患者中，发现了除脑转移以外的其他病因。得出的结论是，头部扫描是检测小细胞肺癌患者中枢神经系统转移的一种敏感且准确的方法。然而，对于无症状的患者，头部计算机断层扫描不应作为初始分期评估的一部分。在60例此类患者中，只有1例脑部扫描改变了初始临床分期，初始临床分期包括胸部X光片、肝脏和骨骼扫描以及骨髓活检。
