Hill C A, North L B, Osborne B M
AJR Am J Roentgenol. 1983 Feb;140(2):259-64. doi: 10.2214/ajr.140.2.259.
Forty-eight female patients who developed bronchogenic carcinoma synchronously with or after the occurrence of breast carcinoma are reported. The object of the study was to review the radiographic findings for possible clues to the diagnosis of bronchogenic carcinoma and to ascertain the histologic diagnoses observed. In 40 patients on whom films were available, the original radiographs before surgery for bronchogenic carcinoma were examined. The clinical records of the 48 patients were also reviewed. Histologic diagnosis of primary bronchogenic carcinoma was required. A solitary pulmonary lesion in a patient with breast carcinoma, a cavitated lesion, or a lesion that failed to respond to appropriate therapy for metastatic breast carcinoma suggested the diagnosis of bronchogenic carcinoma. An increase in the frequency of small cell carcinoma and a decrease in the frequency of adenocarcinoma was seen in bronchogenic carcinomas developing 5 years or more after radiation therapy for breast carcinoma. It was concluded that the benefits of radiation therapy in selected patients far outweighed the risk of bronchogenic carcinoma.
报告了48例在乳腺癌发生同步或之后发生支气管源性癌的女性患者。本研究的目的是回顾影像学表现，寻找支气管源性癌诊断的可能线索，并确定所观察到的组织学诊断。在40例有胸片的患者中，检查了支气管源性癌手术前的原始胸片。还回顾了这48例患者的临床记录。需要对原发性支气管源性癌进行组织学诊断。乳腺癌患者出现孤立性肺部病变、空洞性病变或对转移性乳腺癌的适当治疗无反应的病变提示支气管源性癌的诊断。在乳腺癌放疗5年或更长时间后发生的支气管源性癌中，小细胞癌的发生率增加，腺癌的发生率降低。得出的结论是，对选定患者进行放疗的益处远远超过支气管源性癌的风险。
