Wiernik P H, Sklarin N T, Dutcher J P, Sparano J A, Greenwald E S
Albert Einstein Cancer Center, Bronx, New York, USA.
Med Oncol. 1994;11(3-4):121-5. doi: 10.1007/BF02999859.
Women diagnosed with primary breast or lung cancer and recorded between 1972 and 1989 in our tumor registry were identified. Of 4,123 lung cancer patients and 3,537 breast cancer patients, 42 patients with both diagnoses were identified. The two malignancies were diagnosed simultaneously in five patients, lung cancer was diagnosed first in six patients and breast cancer was diagnosed first in 31 (p < 0.001). Nineteen of those 31 patients received adjuvant radiotherapy for breast cancer and developed lung cancer a median of 17 years later. Of the 19 irradiated patients who subsequently developed lung cancer, 15 did so in the ipsilateral lung and only four had lung cancer contralateral to the previously irradiated site (p < 0.001). Adjuvant radiotherapy for breast cancer as delivered decades ago may be an etiologic factor for lung cancer.
我们确定了1972年至1989年间在我们肿瘤登记处记录的原发性乳腺癌或肺癌女性患者。在4123例肺癌患者和3537例乳腺癌患者中，发现42例同时患有这两种疾病。5例患者同时诊断出这两种恶性肿瘤，6例患者先诊断出肺癌，31例患者先诊断出乳腺癌（p<0.001）。这31例患者中有19例接受了乳腺癌辅助放疗，中位17年后发生了肺癌。在随后发生肺癌的19例接受放疗的患者中，15例在同侧肺发生，只有4例在先前放疗部位的对侧肺发生肺癌（p<0.001）。几十年前进行的乳腺癌辅助放疗可能是肺癌的一个病因。
