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1
In vitro activity of cefodizime (HR-221).头孢地嗪（HR-221）的体外活性
Antimicrob Agents Chemother. 1982 Oct;22(4):715-8. doi: 10.1128/AAC.22.4.715.
2
In vitro antimicrobial activity evaluation of cefodizime (HR221), a new semisynthetic cephalosporin.新型半合成头孢菌素头孢地嗪（HR221）的体外抗菌活性评估
Antimicrob Agents Chemother. 1981 Dec;20(6):760-8. doi: 10.1128/AAC.20.6.760.
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In vitro activity of cefodizime.头孢地嗪的体外活性。
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In vitro activity and beta-lactamase stability of cefodizime, an aminothiazolyl iminomethoxy cephalosporin.氨噻唑基亚胺甲氧基头孢菌素头孢地嗪的体外活性及β-内酰胺酶稳定性
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[In vitro antibacterial activity of cefodizime (HR 221) on 323 hospital strains of Gram negative bacilli. Comparison with cefotiam, cefoperazone, cefotetan and cefotaxime].头孢地嗪（HR 221）对323株医院革兰阴性杆菌的体外抗菌活性。与头孢替安、头孢哌酮、头孢替坦和头孢噻肟的比较
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The in-vitro activity of cefodizime: a review.
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Comparative activities of the oxa-beta-lactam LY127935, cefotaxime, cefoperazone, cefamandole, and ticarcillin against multiply resistant gram-negative bacilli.氧杂β-内酰胺类LY127935、头孢噻肟、头孢哌酮、头孢孟多和替卡西林对多重耐药革兰氏阴性杆菌的比较活性。
Antimicrob Agents Chemother. 1980 Feb;17(2):273-9. doi: 10.1128/AAC.17.2.273.

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The Chemical Relationship Among Beta-Lactam Antibiotics and Potential Impacts on Reactivity and Decomposition.β-内酰胺类抗生素之间的化学关系及其对反应活性和分解的潜在影响。
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Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice.
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本文引用的文献

1
Comparative in vitro activities of cefmenoxime (SCE-1365) and newer cephalosporin derivatives of clinical utility.头孢甲肟（SCE - 1365）与具有临床应用价值的新型头孢菌素衍生物的体外活性比较
Antimicrob Agents Chemother. 1982 Jun;21(6):999-1002. doi: 10.1128/AAC.21.6.999.
2
In vitro antimicrobial activity evaluation of cefodizime (HR221), a new semisynthetic cephalosporin.新型半合成头孢菌素头孢地嗪（HR221）的体外抗菌活性评估
Antimicrob Agents Chemother. 1981 Dec;20(6):760-8. doi: 10.1128/AAC.20.6.760.
3
Beta-lactamase stability and antibacterial activity of cefmenoxime (SCE-1365), a novel cephalosporin.新型头孢菌素头孢甲肟（SCE - 1365）的β-内酰胺酶稳定性及抗菌活性
Antimicrob Agents Chemother. 1981 Aug;20(2):171-5. doi: 10.1128/AAC.20.2.171.

头孢地嗪（HR-221）的体外活性

In vitro activity of cefodizime (HR-221).

作者信息

Ahonkhai V I, Cherubin C E, Shulman M A

出版信息

Antimicrob Agents Chemother. 1982 Oct;22(4):715-8. doi: 10.1128/AAC.22.4.715.

DOI:10.1128/AAC.22.4.715
PMID:6295264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC183824/
Abstract

The in vitro activity of cefodizime (HR-221), a new cephalosporin antibiotic, was compared with the activities of selected antimicrobial agents against a broad spectrum of aerobic bacteria. Cefodizime concentrations of 2 micrograms/ml inhibited about 90% of Enterobacteriaceae studied. Serratia marcescens required 8 micrograms/ml to inhibit 90% of strains. Among gram-positive cocci, 50% of strains were inhibited by 2 micrograms/ml of cefodizime (including methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus faecalis, and penicillin-resistant Streptococcus pneumoniae). Pseudomonas aeruginosa was less susceptible to cefodizime. Cefotaxime, an antibiotic closely related to cefodizime structurally, was about fourfold more active.

摘要

将新型头孢菌素抗生素头孢地嗪（HR - 221）的体外活性与多种选定抗菌剂针对广泛需氧菌的活性进行了比较。2微克/毫升的头孢地嗪浓度可抑制约90%所研究的肠杆菌科细菌。粘质沙雷氏菌需要8微克/毫升才能抑制90%的菌株。在革兰氏阳性球菌中，2微克/毫升的头孢地嗪可抑制50%的菌株（包括耐甲氧西林金黄色葡萄球菌、表皮葡萄球菌、粪肠球菌和耐青霉素肺炎链球菌）。铜绿假单胞菌对头孢地嗪较不敏感。头孢噻肟在结构上与头孢地嗪密切相关，其活性约为头孢地嗪的四倍。