Tkachev A V, Shvareva N V, Gorbachev A L, Berul' I V, Shustova I A
Arkh Anat Gistol Embriol. 1982 Sep;83(9):43-50.
In 15.5-, 16-, 17.5-, 18.5-, 20-day-old fetuses and newborn lemmings, the ultrastructure of the anterior lobe of the hypophysis has been studied. In the parenchyma of the 15.5-day-old fetus gland, some cells containing secretory material are revealed, but they are difficult for identification, since differentiation of their organellas is not completed and polymorphism of their granules is strongly manifested. On the 17.5th day of the prenatal development TTH-, ACTH-, LH-, STH-secreting adenocytes are detected; they include secretory granules having diameters 70--100 nm, 80--150 nm, 60--140 nm and 200--400 nm, respectively. On the 18.5th day FSH-secreting cells are identified. Lactotropocytes appear on the 20th day. The anterior lobe of the hypophysis of 17.5--18.5-day-old fetuses are characterized by a high level of the secretory activity which decreases to some extent before birth. Ultrastructure of the cellular organellas in the newborn hypophysis is similar to that in a mature animal, nevertheless, the diameter of the secretory granules does not reach the size of these elements in mature individuals.
对15.5日龄、16日龄、17.5日龄、18.5日龄、20日龄的胎儿及新生旅鼠的脑垂体前叶超微结构进行了研究。在15.5日龄胎儿腺垂体实质中，可发现一些含有分泌物质的细胞，但因其细胞器分化未完成且颗粒多态性明显，难以鉴定。在产前发育的第17.5天，检测到促甲状腺激素（TTH）、促肾上腺皮质激素（ACTH）、促黄体生成素（LH）、生长激素（STH）分泌性腺细胞；它们分别包含直径为70 - 100纳米、80 - 150纳米、60 - 140纳米和200 - 400纳米的分泌颗粒。在第18.5天，鉴定出促卵泡激素（FSH）分泌细胞。催乳细胞在第20天出现。17.5 - 18.5日龄胎儿的脑垂体前叶分泌活性较高，在出生前会有所下降。新生脑垂体中细胞器的超微结构与成熟动物相似，不过，分泌颗粒的直径未达到成熟个体中这些成分的大小。
