• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Inhibiton of human placental 17 beta-hydroxysteroid dehydrogenase by steroids and nonsteroidal alcohols: aspects of inhibitor structure and binding specificity.

作者信息

Blomquist C H, Kotts C E, Hakanson E Y

出版信息

Arch Biochem Biophys. 1978 Feb;186(1):35-41. doi: 10.1016/0003-9861(78)90460-5.

DOI:10.1016/0003-9861(78)90460-5
PMID:629535
Abstract
摘要

相似文献

1
Inhibiton of human placental 17 beta-hydroxysteroid dehydrogenase by steroids and nonsteroidal alcohols: aspects of inhibitor structure and binding specificity.类固醇和非甾体醇对人胎盘17β-羟基类固醇脱氢酶的抑制作用：抑制剂结构和结合特异性方面
Arch Biochem Biophys. 1978 Feb;186(1):35-41. doi: 10.1016/0003-9861(78)90460-5.
2
17 beta-hydroxysteroid and 20 alpha-hydroxysteroid dehydrogenase activities of human placental microsomes: kinetic evidence for two enzymes differing in substrate specificity.
Arch Biochem Biophys. 1985 May 15;239(1):206-15. doi: 10.1016/0003-9861(85)90828-8.
3
Inactivation of human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase with active site-directed 17 beta-propynyl-substituted progestin analogs.用活性位点导向的17β-丙炔基取代孕激素类似物使人类胎盘17β-雌二醇脱氢酶和20α-羟基类固醇脱氢酶失活。
J Biol Chem. 1982 Mar 25;257(6):2783-6.
4
Microsomal 17 beta-hydroxysteroid dehydrogenase of guinea pig liver: substrate and inhibitor specificity and effects of PH on steroid-enzyme interaction.豚鼠肝脏微粒体17β-羟类固醇脱氢酶：底物和抑制剂特异性以及pH对类固醇-酶相互作用的影响。
Arch Biochem Biophys. 1981 Nov;212(1):63-71. doi: 10.1016/0003-9861(81)90343-x.
5
Inhibition of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activities of human placenta by steroids and non-steroidal hormone agonists and antagonists.
Steroids. 1984 May;43(5):571-86. doi: 10.1016/s0039-128x(84)90204-6.
6
Some kinetic properties of human placental estradiol-17 beta dehydrogenase: patterns of inhibition by adenine nucleotides.
Adv Enzyme Regul. 1978;17:363-71. doi: 10.1016/0065-2571(79)90022-0.
7
17 -Hydroxysteroid dehydrogenase of rat skin. Substrate specificity and inhibitors.
J Biol Chem. 1972 Mar 10;247(5):1407-13.
8
The impact of testosterone, tibolone and black cohosh on purified mammary and placental 17β-hydroxysteroid dehydrogenase type 1.睾酮、替勃龙和黑升麻对纯化的乳腺和胎盘 17β-羟甾类脱氢酶 1 型的影响。
J Enzyme Inhib Med Chem. 2015 Jun;30(3):448-57. doi: 10.3109/14756366.2014.943205. Epub 2014 Aug 11.
9
Inhibition of hepatic 17 beta- and 3 alpha-hydroxysteroid dehydrogenases by antiinflammatory drugs and nonsteroidal estrogens.抗炎药物和非甾体雌激素对肝脏17β-和3α-羟基类固醇脱氢酶的抑制作用。
Enzyme. 1987;37(3):109-14. doi: 10.1159/000469247.
10
Kinetic comparison of the 3 beta-hydroxysteroid dehydrogenase activity in human placenta, chorion laeve, and ovary.
Can J Biochem Cell Biol. 1985 Mar;63(3):183-6. doi: 10.1139/o85-026.

引用本文的文献

1
Synthesis and structure-activity relationships of 2- and/or 4-halogenated 13β- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis.2-和/或 4-卤代 13β-和 13α-雌酮衍生物作为雌激素生物合成酶抑制剂的合成及构效关系。
J Enzyme Inhib Med Chem. 2018 Dec;33(1):1271-1282. doi: 10.1080/14756366.2018.1490731.
2
Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsia implications for vascular dysfunction.子痫前期患者循环雌激素及其代谢物的合成、代谢和血浆蓄积异常与血管功能障碍的关系。
Hypertension. 2013 Feb;61(2):480-7. doi: 10.1161/HYPERTENSIONAHA.111.201624. Epub 2013 Jan 14.
3
Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction.
人类雌激素17β-羟基类固醇脱氢酶的特异性：通过对高度特异性雌酮还原的NADPH依赖性底物抑制进行酶调节。
Biochem J. 2001 May 15;356(Pt 1):269-76. doi: 10.1042/0264-6021:3560269.