Cooperrider P A, Roenigk H H
Arch Dermatol. 1978 Feb;114(2):207-12.
Tests of specific aspects of immune function were conducted on 15 patients with clinically and histologically evident mycosis fungoides of various stages. These tests included peripheral blood lymphocyte counts, T and B cell counts, mitogen stimulation tests to phytohemagglutinin (PHA), concanavalin A (con A), and pokeweed mitogen, as well as determinations of IgE levels and antinuclear factor (ANF). We found that mycosis fungoides patients, as a group, had normal peripheral blood lymphocyte, T cell, and B cell counts, but had decreased stimulation to PHA and con A. When evaluated by stage of disease, the peripheral blood lymphocytes, T and B cell counts did not differ significantly from normal, at least until stage V. Concanavalin A stimulation was decreased by stage II disease, and PHA was decreased by stage III, indicating at least a selective immunological deficit in the plaque stage or in later disease. Values of IgE and ANF were rarely abnormal.
对15例不同阶段临床和组织学表现明显的蕈样肉芽肿患者进行了免疫功能特定方面的检测。这些检测包括外周血淋巴细胞计数、T细胞和B细胞计数、对植物血凝素（PHA）、刀豆蛋白A（con A）和商陆有丝分裂原的有丝分裂原刺激试验，以及IgE水平和抗核因子（ANF）的测定。我们发现，作为一个群体，蕈样肉芽肿患者外周血淋巴细胞、T细胞和B细胞计数正常，但对PHA和con A的刺激反应降低。按疾病阶段评估时，外周血淋巴细胞、T细胞和B细胞计数与正常情况无显著差异，至少在V期之前是这样。刀豆蛋白A刺激在II期疾病时降低，PHA在III期降低，表明在斑块期或疾病后期至少存在选择性免疫缺陷。IgE和ANF值很少异常。
