Jensen J R, Thestrup-Pedersen K, Ahrons S, Zachariae H
Clin Exp Immunol. 1982 Nov;50(2):397-405.
The immune reactivity of 25 patients with mycosis fungoides was studied twice with a 6 month interval using a panel of T lymphocyte surface markers and functional tests. Patients with clinically inactive disease (stage I + II) had normal T lymphocyte biology. Patients with clinically active disease (stage II-IV) had T lymphopenia, alterations in T cell subpopulations (T gamma and T mu) and a reduced lymphocyte reactivity in vitro following mitogen (PHA, Con A, PWM) and antigen (PPD) stimulation. They also had a reduced secretion of immunoglobulin in vitro after PWM stimulation, apparently due to the alterations in their T lymphocyte subpopulations. The observed changes in the peripheral blood T lymphocyte population and the in vitro function of lymphocytes were not shared by lymphocytes from histologically affected lymph nodes. The natural killer cell activity in blood lymphocytes was found to be normal in all patients.
采用一组T淋巴细胞表面标志物和功能试验，对25例蕈样肉芽肿患者的免疫反应性进行了间隔6个月的两次研究。临床无活动期疾病（Ⅰ + Ⅱ期）的患者T淋巴细胞生物学正常。临床活动期疾病（Ⅱ - Ⅳ期）的患者存在T淋巴细胞减少、T细胞亚群（Tγ和Tμ）改变，且在有丝分裂原（PHA、Con A、PWM）和抗原（PPD）刺激后体外淋巴细胞反应性降低。他们在PWM刺激后体外免疫球蛋白分泌也减少，这显然是由于其T淋巴细胞亚群的改变所致。组织学上受累淋巴结的淋巴细胞未出现外周血T淋巴细胞群体及淋巴细胞体外功能的上述变化。所有患者血液淋巴细胞中的自然杀伤细胞活性均正常。
