Nishimura H, Harada T, Nawata J, Hayakawa M, Nishioka M, Takemoto T, Yokoyama T, Takahashi M
Hepatogastroenterology. 1982 Dec;29(6):249-51.
Serum Alkaline Phosphatase (ALP) was studied in relation to liver scintigrams of 54 patients with hepatocellular carcinoma. The ALP activity was higher with larger tumors and in multiple tumors. Within the single tumor group, the activity was higher when the tumor was located in the hilum than in the periphery. The incidence of ALP-1 isoenzyme (bile ALP) roughly paralleled the total ALP activity. These results suggest that the variation of serum ALP seen in each individual patients with hepatocellular carcinoma reflects the volume of cholestatic liver tissue, which is changed by the number, size and localization of the tumor nodules in the liver.
对54例肝细胞癌患者的血清碱性磷酸酶（ALP）与肝脏闪烁扫描图进行了相关性研究。肿瘤越大以及存在多个肿瘤时，ALP活性越高。在单个肿瘤组中，肿瘤位于肝门时的活性高于位于周边时。ALP-1同工酶（胆汁ALP）的发生率大致与总ALP活性平行。这些结果表明，在每例肝细胞癌患者中观察到的血清ALP变化反映了胆汁淤积性肝组织的体积，而该体积会因肝脏中肿瘤结节的数量、大小和位置而改变。
