Schreiber D, Gerlach H, Holzhausen H J
Arkh Patol. 1978;40(1):54-60.
The results of morphological examinations of 78 heart tumors in BD IX rats induced by methyl- and ethylnitrosourea (MNU, ENU) administered by various routes are described. After repeated intravenous or intraperitoneal injections of MNU heart tumors developed in 39--46% of the treated animals. The following localizations were found: left ventricle--55, right ventricle--7, both ventricles--12, other sites--4. In 51 (65.4%) of 78 cases there were early stages of tumor with a ribbon-like lining of the affected ventricle wall. They consisted of elongated stream-like-arranged tumor cells. Large tumor nodules protruding into the ventricular lumen usually showed considerable features of cellular and nuclear polymorphism. The heart tumors were classified as fibromas or neurinoma-like tumors, fibrosarcomas, and polymorphous sarcomas. Histogenetically, the neoplastic cells are probably derived from fibroblasts and Schwann cells.
描述了通过不同途径给予甲基和乙基亚硝基脲（MNU、ENU）诱导BD IX大鼠发生78例心脏肿瘤的形态学检查结果。在多次静脉内或腹腔内注射MNU后，39%-46%的受试动物发生了心脏肿瘤。发现以下定位情况：左心室-55例，右心室-7例，双心室-12例，其他部位-4例。在78例中的51例（65.4%）中，肿瘤处于早期，受累心室壁有带状内衬。它们由细长的、呈束状排列的肿瘤细胞组成。突出于心室腔的大肿瘤结节通常表现出明显的细胞和核多形性特征。心脏肿瘤分为纤维瘤或神经瘤样肿瘤、纤维肉瘤和多形性肉瘤。从组织发生学上看，肿瘤细胞可能来源于成纤维细胞和施万细胞。
