Schreiber D, Gerlach H, Wessel H
Arch Geschwulstforsch. 1976;46(3):169-75.
In continuation of previous own investigations 68 heart tumours including 46 early stages were found in the heart of 590 BD IX rats systematically examined after treatment with methylnitrosourea (MNU) or ethylnitrosourea (ENU). The tumour incidence was about 40% in animals treated by repeated intravenous or intraperitoneal injections of 20 mg per kg body weight MNU. These experiments are suitable for the study of early stages and the histogenetic origin of heart tumours. At present MNU in addition to triazenes (table 5) belongs to the most powerful carcinogens which affect the heart in rats.
在先前自身研究的延续中，在用甲基亚硝基脲（MNU）或乙基亚硝基脲（ENU）处理后进行系统检查的590只BD IX大鼠的心脏中，发现了68个心脏肿瘤，其中包括46个早期肿瘤。通过以每千克体重20毫克的剂量重复静脉内或腹腔内注射MNU处理的动物中，肿瘤发生率约为40%。这些实验适用于研究心脏肿瘤的早期阶段和组织发生起源。目前，MNU除了三氮烯（表5）之外，属于对大鼠心脏影响最强的致癌物。
