Shammas H F, Blodi F C
Arch Ophthalmol. 1978 Mar;96(3):440-5. doi: 10.1001/archopht.1978.03910050216004.
We reviewed 26 cases of peripapillary melanoma, 21 (80.8%) of which extended into the optic nerve or its meningeal sheaths. Most melanomas that extended into the optic nerve were necrotic and of the mixed or epithelioid cell type; all invaded the overlying retina and occurred in blind eyes with secondary glaucoma. The extension of melanoma cells into the subarachnoidal space was only influenced by the presence of the melanoma around the optic nerve head (peripapillary). The prognosis of these patients was highly dependent on the presence of orbital extension. A long piece of optic nerve should be excised when eyes with peripapillary melanomas are enucleated.
我们回顾了26例视乳头周围黑色素瘤病例，其中21例（80.8%）肿瘤已侵犯至视神经或其脑膜鞘。多数侵犯至视神经的黑色素瘤呈坏死状，为混合型或上皮样细胞型；所有肿瘤均侵犯了上方的视网膜，且均发生于继发青光眼的盲眼中。黑色素瘤细胞向蛛网膜下腔的侵犯仅受视乳头周围（视乳头周围）黑色素瘤的存在情况影响。这些患者的预后高度依赖于眼眶侵犯的存在情况。对视乳头周围黑色素瘤患者行眼球摘除术时，应切除一段较长的视神经。
