Brown G C, Shields J A
Br J Ophthalmol. 1982 Feb;66(2):77-82. doi: 10.1136/bjo.66.2.77.
The clinical and histopathological findings in the eyes of 2 patients with diffuse malignant melanoma of the choroid are described. The tumours were minimally elevated and nonpigmented in the peripapillary area, and both had an associated nonrhegmatogenous retinal detachment. Extension of the tumour into the region of the lamina choroidalis in each eye appeared to cause a localised constriction of the optic nerve and subsequent swelling of the optic nerve head. In addition tumour infiltration of the nerve head was present in one eye. Ophthalmoscopic, fluorescein angiographic, and ultrasonographic characteristics that differentiate between extensive tumour infiltration of the optic nerve head and swelling secondary to other causes are presented. The importance of appreciating this difference clinically is discussed.
描述了2例脉络膜弥漫性恶性黑色素瘤患者眼部的临床和组织病理学表现。肿瘤在视乳头周围区域轻度隆起且无色素沉着，二者均伴有非孔源性视网膜脱离。每只眼中肿瘤向脉络膜板层区域的延伸似乎导致了视神经的局部狭窄以及随后视乳头的肿胀。此外，一只眼中存在肿瘤对视乳头的浸润。介绍了能够区分视神经乳头广泛肿瘤浸润与其他原因导致的肿胀的检眼镜、荧光素血管造影和超声特征。讨论了临床上认识这种差异的重要性。
