Rogoz I, Zaharia D, Georgescu I
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1982 Jul-Sep;31(3):195-9.
In spite of the fact that tuberculosis in children is continuously declining (in the Brasov District it fell from 197 cases during 1960-1970 to 67 between 1977 and 1979), a large number of cases are still recorded in children under the age of 3 years (from a percentage of 23 of the total number of sick children in 1969 to 44.8 in the last period). Epidemiologic studies discovered infection sources in 91% of the vaccinated children (parents represented 68% of all sources). Thus the source in the proximity, and detectable through the epidemiologic investigation exceeds the protection provided by the BCG vaccination, which results in a better protection against extra-familial infections, more rare and sporadic. It appears that in tuberculosis sources BCG vaccination alone is less efficient and a more prompt application of other preventive measures should be considered, such as early detection, rapid removal of the source, removing the children from the infective environment. Considerations should also be given to a control of the parents, especially of the father, which appears to be the source of infection twice as frequently as the mother.
尽管儿童结核病的发病率持续下降(在布拉索夫区,从1960 - 1970年的197例降至1977 - 1979年的67例),但3岁以下儿童的病例仍大量存在(从1969年占患病儿童总数的23%上升到最近时期的44.8%)。流行病学研究发现,91%的接种疫苗儿童有感染源(父母占所有感染源的68%)。因此,通过流行病学调查可发现的近距离感染源超过了卡介苗接种所提供的保护,这使得对家庭外感染(更为罕见和散发)有了更好的防护。看来在结核病感染源方面,仅靠卡介苗接种效果较差,应考虑更迅速地采取其他预防措施,如早期检测、迅速隔离感染源、让儿童脱离感染环境。还应考虑对父母进行管控,尤其是父亲,因为父亲作为感染源的频率似乎是母亲的两倍。