Rotarn G, Lăzărescu I
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1982 Jul-Sep;31(3):235-44.
The effects have been studied of some pure charcoal powder, and of mixed "coal pit" powder which are representative for the basin in the Jiu Valley. A total of 48 samples have been studied as such and after addition of quartz graduated to contain 5, 10, 15, 20 and 25% quartz. The aim of the study was to determine the type of pneumoconioses induced by the various powders, to establish the role of quartz particles and the threshold at which quartz addition will impart silicogenic properties to the dust particles. A total of 300 Wistar rats have received intra-tracheal doses of an unique amount of 50 mg suspension as such and with added quartz. The rats were distributed in 12 groups. Three animals in each group were sacrificed at 6 and 12 months after instillation and histopathologic studies of the lungs were performed. Addition of 10% quartz dust to the charcoal powder, and of 15% to the "coal pit" powder imparted silicogenic properties to the samples. Both powders have masked to a certain extent the effects of the added quartz, the protective effects being exerted by minerals associated to charcoal (silicates, metallic oxides, etc.). In the mining area investigated pneumoconioses and silicosis represent two distinct pathological entities, and the role of the quartz particles in the genesis of pneumoconioses in this particular area appears to be limited.
已经对一些纯木炭粉以及代表 Jiu 山谷盆地的混合“煤窑”粉的影响进行了研究。总共对 48 个这样的样品以及添加了按比例含有 5%、10%、15%、20%和 25%石英的样品进行了研究。该研究的目的是确定各种粉末诱发的尘肺病类型，确定石英颗粒的作用以及石英添加量达到何种阈值会使粉尘颗粒具有致硅肺特性。总共 300 只 Wistar 大鼠经气管内给予了 50 毫克这样的悬浮液以及添加了石英的悬浮液的单一剂量。这些大鼠被分为 12 组。每组三只动物在滴注后 6 个月和 12 个月时被处死，并对肺部进行组织病理学研究。向木炭粉中添加 10%的石英粉尘以及向“煤窑”粉中添加 15%的石英粉尘会使样品具有致硅肺特性。两种粉末在一定程度上都掩盖了添加石英的影响，保护作用由与木炭相关的矿物质（硅酸盐、金属氧化物等）发挥。在所调查的矿区，尘肺病和矽肺病是两种不同的病理实体，石英颗粒在该特定区域尘肺病发生过程中的作用似乎有限。
