Mazzocchi G, Meneghelli V, Nussdorfer G G
Acta Endocrinol (Copenh). 1983 Jan;102(1):129-35. doi: 10.1530/acta.0.1020129.
The trophic effects of angiotensin II on the rat zona glomerulosa were investigated by stereological and radioimmunological methods. Angiotensin II was not able to reverse the sodium-loading and dexamethasone-induced inhibition of the growth and steroidogenic capacity of the zona glomerulosa. However, if the sodium-loaded dexamethasone-treated rats were given maintenance doses of ACTH, angiotensin II exerted a strong adrenoglomerulotrophic effect. The hypothesis is advanced that the co-operation of ACTH and angiotensin II is required in the maintenance of the morphologic and enzymatic integrity of the rat zona glomerulosa.
通过体视学和放射免疫学法研究了血管紧张素II对大鼠肾小球带的营养作用。血管紧张素II无法逆转钠负荷和地塞米松诱导的对肾小球带生长和类固醇生成能力的抑制。然而，如果给钠负荷且经地塞米松处理的大鼠给予促肾上腺皮质激素维持剂量，血管紧张素II会发挥强烈的肾上腺肾小球营养作用。有人提出假说，认为促肾上腺皮质激素和血管紧张素II的协同作用是维持大鼠肾小球带形态和酶完整性所必需的。
